Treatment of atrophic acne scars: A comparative split face study

Treatment of atrophic acne scars: A comparative split face study

A study published in 2023 by Albalat et al. compared microneedling in combination with topical platelet-rich plasma versus its combination with topical Botulinum Toxin-A in treatment of atrophic acne scars.

Atrophic post-acne scarring is a common cosmetic concern. This study aimed to compare the effectiveness of micro needling in combination with two different treatments, platelet-rich plasma (PRP) and Botulinum Toxin-A (Botox), for improving these scars.

• 30 participants with various types and grades of atrophic post-acne scars were involved.• One side of their face was treated with micro needling and PRP, while the other received micro needling and Botox.

• The study assessed the effectiveness of the treatment using two different scales and evaluated patient satisfaction and pain levels.

• There was a statistically significant improvement on both sides, with higher improvement on the right side (with PRP ) than the left side (with Botox), but in a non-statistically significant way.

• The results showed no significant difference in the treatment response between the two sides, with both combinations leading to improvements.

• Both micro needling with PRP and micro needling with Botox were effective options for treating acne scars.


Albalat, W., Ghonemy, S., Saleh, A., & Elradi, M. (2023). Microneedling combined with botulinum toxin-A
versus microneedling combined with platelet-rich plasma in treatment of atrophic acne scars: a comparative
split face study. Archives of Dermatological Research, 315(4), 839-846.